The article analyzes the mediation activities of international organizations in the Nagorno-Karabakh conflict from 1992 to 2020. The positions of the OSCE, the United States, Russia, as well as Armenia, Azerbaijan and Nagorno-Karabakh regarding the plans for a peaceful settlement of the conflict are examined. The key role of the Russian Federation as a major regional factor in the reconciliation of the warring parties and the resolution of the Nagorno-Karabakh problem is considered.